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Spontaneous tumour lysis syndrome in multiple myeloma with loss of 17p13.1, t(4;14) and monosomy 13
  1. Bushra Tbakhi1,
  2. Sandrine Hanna2,
  3. Yazan Samhouri3 and
  4. Deeraj Lingutla2
  1. 1Hematology/Oncology, University of Rochester, Rochester, New York, USA
  2. 2Internal Medicine, Unity Hospital, Rochester, New York, USA
  3. 3Hematology/Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Dr Bushra Tbakhi; bushra_tbakhi{at}urmc.rochester.edu

Abstract

Tumour lysis syndrome (TLS) is a constellation of metabolic derangements caused by lysis of tumour cells. It is an oncological emergency that is considered a rare occurrence in multiple myeloma (MM) and usually occurs after patients have been treated with chemotherapy. We describe a very rare case of TLS occurring before the official diagnosis or treatment of MM. We report infrequent karyotype abnormalities, including loss of 17p13.1 (TP53 mutation), t(4;14) (FGFR3/IGH fusion) and monosomy 13, that have not been explicitly described in association with spontaneous tumour lysis syndrome (STLS) in MM. This case adds to the sparse literature available on STLS in MM, which is a life-threatening situation requiring urgent medical intervention.

  • haematology (drugs and medicines)
  • calcium and bone
  • malignant and Benign haematology
  • acute renal failure
  • dialysis

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Footnotes

  • Contributors We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed.All persons who meet authorship criteria are listed as authors, and all authors certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, writing or revision of the manuscript. Furthermore, each author certifies that this material or similar material has not been and will not be submitted to or published in any other publication before its appearance in the Journal of BMJ Case Reports. Category 1: conception and design of study: BT; acquisition of data: BT and SH; analysis and/or interpretation of data: BT, SH and YS. Category 2: drafting the manuscript: BT and SH; revising the manuscript critically for important intellectual content: YS and DL. Category 3: approval of the version of the manuscript to be published: BT, SH, YS and DL. The attending/consultant in charge of this case was DL.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.