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Case report
Ribociclib-associated organising pneumonia
  1. Arjun Rajendran1,
  2. Akhilesh Kunoor2,
  3. Roshini Pushpa Ragahavan1 and
  4. Pavithran Keechilat3
  1. 1Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India
  2. 2Department of Respiratory Medicine, Amrita Institute of Medical Science, Amrita Viswa Vidyapeetham, Cochin, Kerala, India
  3. 3Medical Oncology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India
  1. Correspondence to Arjun Rajendran; arjun.rageandu.96{at}gmail.com; Ms Roshini Pushpa Ragahavan; roshnivipin{at}gmail.com

Abstract

A 63-year-old woman with grade 2 infiltrating left breast carcinoma who was started on ribociclib complained of exertional dyspnoea along with dry cough. There were bilateral interscapular crackles and chest X-ray evidence of bilateral mid and lower zone non-homogeneous opacity. The patient’s pulmonary function test (PFT) showed moderate restrictions and desaturation. CT was suggestive of organising pneumonia and drug administration was stopped. The patient was treated with steroids in tapering doses, which led to improvements. The drug was restarted with the probability of other aetiologies for interstetial lung disease (ILD). It was also considered the superior efficacy of ribociclib in managing breast cancer. But due to evidence indicating the reappearance of organising pneumonia following drug administration, it was again stopped, and steroid use was restarted for treatment. The patient showed improvements in subsequent follow-ups.

  • breast cancer
  • interstitial lung disease
  • pneumonia (respiratory medicine)

http://dx.doi.org/10.1136/bcr-2021-245187

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    Footnotes

    • Contributors AR contributed to planning of the study, conduct of the study, reporting of the study, design of the study, acquisition of data and analysis and interpretation of data. AK contributed to planning of the study, conduct of the study, reporting of the study, conception of the study, design of the study, interpretation of data, analysis of data. PK contributed to reporting of the study, acquisition of data and analysis, interpretation of data and analysis. RPR contributed to conduct of the study, reporting of the study, acquisition of data and analysis, analysis of data.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.