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Ovarian hyperstimulation syndrome: cardiac arrest with an unexpected outcome
  1. Jonathan Gaughran1,
  2. Tom Lyne2,
  3. Julia Kopeika3 and
  4. Judith Hamilton1
  1. 1Departement of Gynaecology, Guy’s and St Thomas’ Hospitals NHS Trust, London, UK
  2. 2School of Medical Education, King’s College London, London, UK
  3. 3Assisted Conception Unit, Guy’s and St Thomas’ Hospitals NHS Trust, London, UK
  1. Correspondence to Dr Jonathan Gaughran; gaughraj{at}


We describe the acute deterioration of a 29-year-old undergoing in vitro fertilisation. Late-onset critical ovarian hyperstimulation syndrome triggered a massive pulmonary embolism and subsequent cardiac arrest. While the prognosis was deemed to be poor, the patient made a full recovery. The potential reasons for this are explored.

  • venous thromboembolism
  • obstetrics
  • gynaecology and fertility
  • ultrasonography
  • pulmonary embolism

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  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Contributors First author (JG) cared for the patient and planned the writing of the report, obtained consent and took overall responsibility for write up. Second author (TL) performed the literature review and assisted in writing the introduction and discussion. Third and fourth authors (JK and JH) cared for the patient and offered expert opinion on the case and made corrections to the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.