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Lithium neurotoxicity with electroencephalogram changes
  1. Hui Jan Tan,
  2. Kuan Yee Lim,
  3. Rathika Rajah and
  4. Chen Fei Ng
  1. Department of Medicine, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
  1. Correspondence to Dr Hui Jan Tan; tanhuijan{at}


Lithium is a medication with a variety of medical usage for various diseases including bipolar mood disorder. As the therapeutic window of lithium is narrow, its usage is commonly associated with toxicity. Lithium toxicity affects multiple systems especially the central nervous system, leading to neuropsychiatric complications. Haemodialysis is an effective method for lithium removal especially in severe lithium toxicity such as neurotoxicity with electroencephalogram changes. We describe a case of lithium neurotoxicity with electroencephalographic abnormalities which was reversed following haemodialysis.

  • neurology (drugs and medicines)
  • psychiatry (drugs and medicines)

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  • Permission Permission was obtained for the publication.

  • Contributors Conception or design of the work, or the acquisition, analysis, or interpretation of data for the work by HJT, KYL, RR and CFN. Draft and revision of the manuscript by HJT, KYL, RR, and CFN. HJT, KYL, RR and CFN approved the final version of the manuscript to be published. HJT, KYL, RR and CFN agreed to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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