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COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de Quervain’s thyroiditis
  1. Mohammad Sadiq Jeeyavudeen1,
  2. Alan W Patrick1,
  3. Fraser W Gibb1,2 and
  4. Anna R Dover1,2
  1. 1Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
  2. 2Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr Anna R Dover; anna.r.dover{at}


Subacute thyroiditis following vaccination is an uncommon presentation of thyrotoxicosis. As the world undertakes its largest immunisation campaign to date in an attempt to protect the population from COVID-19 infections, an increasing number of rare post vaccine side effects are being observed. We report a case of a middle-aged woman who presented with painful thyroid swelling following the second dose of the COVID-19 mRNA vaccine BNT162b2 (Pfizer–BioNTech) with clinical, biochemical and imaging features consistent with destructive thyrotoxicosis. Symptomatic management only was required for the self-limiting episode. Thyroiditis typically has a mild and self-limiting course and thus this observation should not deter people from vaccination, as COVID-19 infection has a far greater morbidity and mortality risk than thyroiditis.

  • endocrine system
  • immunological products and vaccines
  • thyroid disease

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  • Contributors MSJ and ARD were involved in the primary evaluation and management of the patient and conception and drafting of the case report. FG and AWP were involved in reviewing the existing literature and revising the report. ARD is the guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.