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Signet ring cell carcinoma of bladder: a dilemma between primary and metastatic
  1. Zaibun Nisa
  1. Cellular Pathology, Queen's Hospital, Romford, London, UK
  1. Correspondence to Dr Zaibun Nisa; dr.zaibunnisa{at}


Signet ring cell carcinoma, in general, is a peculiar tumour. There is always a query regarding its exact site of origin. Even, immunohistochemistry shows overlapping staining patterns between various sites. On one hand, signet ring cell carcinoma of the bladder is a rare occurrence, but on the other hand metastatic signet ring cell carcinoma to the bladder is not uncommon. However, without prior knowledge of the primary site of tumour clinically and radiologically, definitive diagnosis is challenging based on morphology and immunohistochemistry.

  • urological cancer
  • pathology
  • gastric cancer
  • malignant disease and immunosuppression
  • surgical oncology

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  • Contributors Reporting of case and compilation of case report was done by me, the sole author. No one contributed as co-author in this case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.