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Corynebacterium freneyi as a cause of early prosthetic valve endocarditis
  1. Bjørnar Grenne1,2,
  2. Håvard Dalen1,2,3,
  3. Dag Ole Nordhaug2,4,
  4. Torgeir Sand-Aas2,5,
  5. Espen Holte1,2,
  6. Jan Kristian Damås6,7 and
  7. Ole Christian Mjølstad1,2
  1. 1Clinic of Cardiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
  2. 2Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
  3. 3Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
  4. 4Clinic of Cardiothoracic Surgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
  5. 5Department of Medicine, Molde Hospital, Molde, Norway
  6. 6Department of Infectious Diseases, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
  7. 7Faculty of medicine and health sciences, Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  1. Correspondence to Dr Bjørnar Grenne; bjornar.grenne{at}


Infective endocarditis (IE) is associated with severe complications and a high mortality rate. Identification of the causative pathogen is crucial to optimise treatment. We present a case of prosthetic valve endocarditis caused by Corynebacterium freneyi, a very rare cause of human infection and not previously reported as a cause of IE. Despite proper antibiotic therapy, the patient eventually needed surgery after progression of the infection. After surgery, he quickly recovered without evidence of relapse during an 8-month follow-up period. This report highlights critical decision making in a complex and potentially life-threatening situation, where neither guidelines nor previous clinical or microbiological experience were able to give clear treatment recommendations.

  • cardiovascular medicine
  • valvar diseases
  • infections
  • infectious diseases
  • cardiothoracic surgery

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  • Contributors Each author contributed to the concept and design of this manuscript. All authors were central members in decisions on diagnostics and handling as part of the endocarditis team. BG, HD, EH and TS-A were central to the diagnostic work-up, acquired echo images and had the main responsibility for follow-up after surgery. DON was the chief surgeon and contributed importantly to the surgical perspective throughout the manuscript. OCM was central for decisions on the patient treatment, and in particular, handling of the pacemaker. JKD was a key member of the endocarditis team with profound knowledge in infectious medicine and contributed importantly to the infectious medicine and microbiology perspective of the manuscript. BG drafted the manuscript and prepared the illustrations. All authors contributed importantly to the final manuscript and have read the final version. All authors are accountable for the manuscript and its content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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