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Anti-NMDAR encephalitis presenting after immature teratoma resection
  1. Deandra Kimberly Chetram1,
  2. Kelsey Pan2,
  3. Aisha Elfasi3 and
  4. Merry Markham4
  1. 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Internal Medicine, University of Florida Health, Gainesville, Florida, USA
  3. 3Neurology, University of Florida Health, Gainesville, Florida, USA
  4. 4Medicine, Division of Hematology & Oncology, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Kelsey Pan; kelsey.pan{at}ufl.edu

Abstract

This is a case of a young woman who developed neurological and psychiatric symptoms 3 days after resection of an immature teratoma. She was diagnosed with anti-NMDA receptor encephalitis via positive serum antibody titres, which was later confirmed with cerebrospinal fluid antibody titres. Given her cancer diagnosis, she underwent treatment with bleomycin, etoposide and cisplatin chemotherapy in addition to 5 days of high-dose steroids (1 g of intravenous methylprednisolone) for the encephalitis. This treatment regimen led to significant clinical improvement 3 weeks after completion of one cycle of chemotherapy.

  • cancer intervention
  • gynaecological cancer
  • neurology

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Footnotes

  • Twitter @DrMarkham

  • Contributors DC and KP were involved in conception/ design. DC, KP, AE and MM

    were involved in provision of study material or patients. DC, KP, AE and MM were involved in collection/ assembly of data. DC, KP, AE and MM were involved in manuscript writing. DC, KP, AE and MM were involved in final approval of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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