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Primary high-grade diffuse large B-cell lymphoma of the glans penis
  1. Marylou Fenech1,
  2. David Pisani2 and
  3. David James Camilleri1
  1. 1Haematology Department, Mater Dei Hospital, Msida, Malta
  2. 2Pathology Department, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Dr Marylou Fenech; marylou.fenech{at}


Diffuse large B-cell lymphoma (DLBCL) of the penis is a rare haematological malignancy, with less than 30 cases being reported in the literature. Our case mentions a 57-year-old man who presented with a penile lesion that was diagnosed as DLBCL on histological biopsy. Targeted investigation and proper diagnosis are essential to distinguish it from squamous cell carcinoma (SCC) of the glans, which presents similarly. Since guidelines are not available, the author compared different management mentioned in case reports and the outcome was noted. Chemotherapy, radiotherapy and surgery were the treatment modalities most used; out of which, chemotherapy had the most successful outcome. On the other hand, surgery is the preferred modality in SCC of the penis. This further consolidates the need for guidelines with regard to proper diagnosis and management of this malignancy.

  • haematology (incl blood transfusion)
  • urology
  • dermatology

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  • Contributors MF was involved in the writing and research of this case report. DP kindly supplied and edited the histological images included in the report. DJC was involved in proof reading and guidance throughout the process.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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