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Gemtuzumab-ozogamicin and blinatumomab as treatment for refractory mixed-phenotype blast crisis in chronic myeloid leukaemia
  1. Roberto Ovilla-Martinez1,
  2. Luis Alejandro Weber Sánchez1,2,
  3. Xóchitl Cota-Rangel1 and
  4. Pamela Elena Baez-Islas1
  1. 1Hematology Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico
  2. 2Surgery Department, Hospital Angeles Lomas, Huixquilucan, Estado de Mexico, Mexico
  1. Correspondence to Dr Pamela Elena Baez-Islas; drabaez.hematologia{at}gmail.com

Abstract

In the tyrosine kinase inhibitor era, the blast phase of chronic myeloid leukaemia (BP-CML) renders an uncommon presentation and has a poor prognosis with an estimated overall survival below 20%. Mixed-phenotype blast phase is even more infrequent, presenting in 3.3% of these patients. Blast phase manifests along haematological sarcomas, with extramedullary activity in lymph nodes, skin and bone. We report the case of a patient with an ovarian sarcoma as an extramedullary presentation of mixed-phenotype BP-CML refractory to conventional treatment which responded to immunotherapy against CD33 and CD19.

  • cancer - see oncology
  • chronic myeloid leukaemia
  • haematology (drugs and medicines)
  • haematology (incl blood transfusion)

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Footnotes

  • Contributors RO-M, XC-R and PEB-I were responsible for the hemato-oncological treatment of the patient. LAWS was responsible for the surgical treatment of the patient. The original idea was conceived by RO-M. The text was written by PEB-I. The images were provided by LAWS. All authors contributed to the investigation and discussion of the case.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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