You are here

Article Text

Article menu
Download PDFPDF
Case report
Sustained viral suppression with dolutegravir monotherapy in a treatment-experienced adult with perinatally acquired HIV
  1. Wei Li Adeline Koay1,2,
  2. Eleanor D Sadler3,
  3. Kathleen Ferrer2,4 and
  4. Natella Y Rakhmanina1,2,5
  1. 1Division of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA
  2. 2The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
  3. 3Division of Infectious Diseases, The Mount Sinai Hospital, New York, New York, USA
  4. 4Division of Hospital Medicine, Children's National Hospital, Washington, District of Columbia, USA
  5. 5Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA
  1. Correspondence to Dr Wei Li Adeline Koay; wkoay{at}childrensnational.org

Abstract

We report a case of sustained viral suppression with dolutegravir monotherapy in a treatment-experienced adult with perinatally acquired HIV. The patient had recurrent pancreatitis with multiple antiretroviral drugs, leading to discontinuation of antiretroviral therapy for several years. She was ultimately initiated on dolutegravir monotherapy two times per day via a gastrostomy tube. She did not develop any integrase strand transfer inhibitor mutations during the first 2 years on dolutegravir monotherapy. The patient has successfully maintained prolonged viral suppression for over 3 years with intermittent blips secondary only to intermittent medical issues. This case is unique in describing a highly treatment-experienced young adult with perinatal HIV infection who has been virally suppressed on dolutegravir monotherapy for a prolonged follow-up of 156 weeks.

  • HIV / AIDS
  • infections

https://doi.org/10.1136/bcr-2021-243685

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors WLAK and EDS wrote the initial draft of this case report. KF and NYR revised it critically for important intellectual content. WLAK, KF and NYR provided clinical care for the patient described in this case report. All authors contributed substantially to the work, approved the final version of this case report and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.