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IgG4-related tubulointerstitial nephritis
  1. Tasnim Momoniat1,
  2. Deepa Jacob2,
  3. Neelaveni Duhli2 and
  4. Tom Jorna1
  1. 1Renal Department, Hull Royal Infirmary, Hull, UK
  2. 2Histopathology Department, Hull Royal Infirmary, Hull, UK
  1. Correspondence to Dr Tasnim Momoniat; tasnim.momoniat{at}


A 67-year-old man was referred to the renal team following an episode of acute kidney injury on a background of chronic kidney disease. He had a 9-year history of steroid-sensitive arthritis, epigastric pain and isolated submandibular gland enlargement. He was noted to have a raised eosinophil count, total serum protein and total immunoglobulin G4 (IgG4) level as well as a serum hypocomplementaemia. A renal biopsy showed a tubulointerstitial nephritis with lymphoplasmacytic infiltrates, fibrosis and IgG4-positive plasma cells on immunohistochemistry. A diagnosis of IgG4-related disease was made based on clinical presentation and pathology. Renal function improved with glucocorticoids and the patient was successfully transitioned to azathioprine as a steroid-sparing agent.

  • acute renal failure
  • rheumatology
  • renal medicine
  • ear
  • nose and throat/otolaryngology

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  • Contributors This manuscript was written by TM, which included review of the medical notes and literature as well as production of the submitted article and subsequent revisions. DJ and ND provided and reported the histology slides and also reviewed the manuscript and made some revisions. Overall supervision for the project was provided by TJ. All work was reviewed at multiple intervals by TJ and revised as required.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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