Article Text

Download PDFPDF
Takotsubo (stress) cardiomyopathy after ChAdOx1 nCoV-19 vaccination
  1. Phillip Crane1,
  2. Chiew Wong1,2,
  3. Nilesh Mehta1 and
  4. Peter Barlis1,2
  1. 1Department of Cardiology, Northern Health NCHER, Epping, Victoria, Australia
  2. 2Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
  1. Correspondence to Dr Phillip Crane; phillipgcrane{at}


The global COVID-19 pandemic remains challenging with efforts for community vaccination the primary strategy to control transmission and disease sequalae in the mid to long term. While several candidate vaccines have been approved for use, there is an ongoing discussion regarding potential vaccine-related adverse events. Notably, thrombotic thrombocytopaenia has been reported following ChAdOx1 nCov-19 (AstraZeneca) vaccination. We report the first known case of takotsubo (stress) cardiomyopathy 4 days after administration of the ChAdOx1 nCoV-19 vaccine in a 72-year-old man. While this condition remains one primarily seen in females, our case represents a new trigger that warrants careful consideration when assessing patients presenting with acute coronary syndromes following ChAdOx1 nCoV-19 vaccination.

  • Heart failure
  • COVID-19
  • Drug interactions
  • Global Health
  • Vaccination/immunisation

This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors PC was involved in the conception, design, acquisition of data and drafting of the article. CW was involved in data and imaging acquisition and analysis, and final approval of version published. NM involved in care of patient, imaging investigation, exclusion of differentials and final approval of version published. PB was supervising author involved in all stages of case, from formulation, drafting, interpretation and final approval of version published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.