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Isolated splenic sarcoidosis: a rare cause of hypercalcaemia in a patient with type 1 diabetes
  1. Hafiz Muhammad Zubair Ullah1,
  2. Ashutosh Surya1,
  3. Nicholas Morley2 and
  4. Sajjad Ahmad1
  1. 1Deaprtment of Diabetes and Endocrinology, University Hospital of Wales, Cardiff, UK
  2. 2Department of Nuclear Medicine, Velindre Cancer Centre, Cardiff, UK
  1. Correspondence to Dr Sajjad Ahmad; drsajjad618{at}


A 30-year-old man was admitted to Intensive Therapy Unit (ITU) with status epilepticus secondary to severe hypoglycaemia on a background of type 1 diabetes. CT of the brain showed generalised cerebral oedema. He was successfully stepped down to a medical ward after 2 weeks. He was noted to have persistently high calcium, which required multiple doses of pamidronate. Parathyroid hormone level was appropriately low. CT of the thorax, abdomen and pelvis showed mild hepatosplenomegaly with small pathological lymph nodes throughout the abdomen. Bone marrow biopsy was unremarkable. Lymph node biopsy was difficult to achieve, and therefore a positron emission tomography scan was arranged. This showed an enlarged and hypermetabolic spleen. Differential diagnoses at this point included lymphoma and sarcoidosis. He underwent diagnostic splenectomy, and the diagnosis of sarcoidosis was confirmed histologically. Calcium level remained normal 17 months after splenectomy.

  • epilepsy and seizures
  • chronic renal failure

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  • Contributors SA was the responsible consultant physician and endocrinologist, wrote case report and discussion and performed literature search for previous case reports; HMZU helped in writing case report and analysed the data in the previous case reports; AS helped in writing case report and obtained histological images; NM provided radiological/PET images with specialist comments on findings.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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