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Intraosseous solitary myofibroma of the orbit in an adolescent woman
  1. Ruchi Goel1,
  2. Ayushi Agarwal1,
  3. Shweta Raghav1 and
  4. Ravindra Kumar Saran2
  1. 1Ophthalmology, Maulana Azad Medical College, New Delhi, India
  2. 2Pathology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India
  1. Correspondence to Professor Ruchi Goel; gruchi1{at}


A 16-year-old woman presented with a painless, progressive, hard swelling in the left inferolateral orbital wall for the past 1 year. There was no diminution of vision or limitation of ocular motility. Imaging revealed an intraosseous, well-defined, expansile, soft tissue lesion in the inferolateral wall of the left orbit. A left anterior orbitotomy with complete surgical excision was performed. Histopathological evaluation of the specimen revealed fascicular pattern of spindle cells with a rich network of slit-like, branching blood vessels. Tumour cells exhibited smooth muscle actin and vimentin positivity but were negative for CD-34 and STAT-6. In absence of any systemic manifestation, a diagnosis of intraosseous solitary orbital myofibroma was made. The case highlights the importance of integrating clinical, radiological and histopathological features in overcoming the diagnostic challenge of differentiating myofibroma from other mesenchymal neoplasms. It also brings forth the importance of complete resection and curettage to prevent recurrence.

  • ophthalmology
  • pathology

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  • Contributors AA, SR and RG drafted the manuscript, edited the images and did the literature search. RG, AA, RKS and SR edited and finalised the manuscript. RG and SR managed the patient. RKS helped in reaching the diagnosis and interpreted the histopathological images. RG is the corresponding author and assumes responsibility for the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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