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Severe fetal anaemia caused by congenital cytomegalovirus infection
  1. Claudia Salazar-Sanchez1,
  2. Pedro Llancarí1,
  3. Rommy H Novoa1 and
  4. Walter Ventura1,2
  1. 1Department of Obstetrics and Perinatology, Instituto Nacional Materno Perinatal, Lima, Peru
  2. 2Fetal Medicine Unit, Grupo CERAS, Clínica Anglo Americana, Lima, Peru
  1. Correspondence to Dr Walter Ventura; walterichard{at}


A 22-year-old pregnant woman was referred to our fetal medicine unit due to severe fetal growth restriction at 26 weeks of gestation. An extensive detailed ultrasound revealed signs of bilateral periventricular hyperechogenicity, suggesting fetal infection potentially due to cytomegalovirus (CMV). Doppler ultrasound showed a high peak systolic velocity in the middle cerebral artery. Percutaneous umbilical cord blood sampling confirmed fetal CMV infection and severe fetal anaemia. We present this case to highlight the importance of fetal anaemia, which can be fatal regardless of whether it is associated with generalised oedema or hydrops fetalis.

  • pregnancy
  • materno-fetal medicine

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  • Twitter @PedroLlancari, @RommyHelena

  • Contributors CSS was responsible for the conception and design of the study. Data acquisition was performed by CSS and PLL. Analysis and interpretation of data were performed by RHN, CSS and WV. CSS wrote the first draft, and critical revision of publication was done by WV. Supervision was done by RHN and WV.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.