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Primary synchronous malignancies of the breast and the kidney
  1. Rehan Nasir Khan1,
  2. Zehra Kazmi1,
  3. Lubna Mushtaque Vohra1 and
  4. Zeeshan Uddin2
  1. 1Surgery, Aga Khan University, Karachi, Pakistan
  2. 2Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan
  1. Correspondence to Dr Rehan Nasir Khan; doc.rnk{at}


Synchronous primary malignancies are most frequently seen with cancers of the stomach and oesophagus, mainly attributed to the similar genetic mutations. Most of these multiple malignancies turn out to be metastatic or metachronous lesions. Multiple synchronous malignancies are rarer than metachronous ones. Primary synchronous breast and renal cancer is even rare. These patients require extensive workup to exclude all possible metastases. The nature of the primary tumours must also be confirmed, prior to any treatment strategy. We report the case of a healthy, middle-aged woman who initially presented with a lesion suspicious for breast carcinoma, and further workup revealed the presence of an asymptomatic, synchronous primary renal cell cancer, which is a very rare presentation.

  • breast cancer
  • urological cancer

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  • Contributors RNK, ZK, LMV and ZU: conception and design, acquisition of data or analysis and interpretation of data. Drafting the article. Final approval of the version published. Agreement to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.