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Hypereosinophilia: a rare cause of stroke and multiorgan dysfunction
  1. Kapil L Barbind1,
  2. Revanth Boddu2,
  3. KP Shijith3 and
  4. Kundan Mishra2
  1. 1Department of Internal Medicine, Army Hospital Research and Referral, New Delhi, Delhi, India
  2. 2Department of Clinical Hematology, Army Hospital Research and Referral, New Delhi, Delhi, India
  3. 3Department of Radiodiagnosis, Army Hospital Research and Referral, New Delhi, Delhi, India
  1. Correspondence to Dr Kundan Mishra; mishrak20{at}


Eosinophilia can occur due to a plethora of allergic, infective, neoplastic and idiopathic conditions. Hypereosinophilic syndrome (HES) is characterised by sustained eosinophilia and multiorgan dysfunction in the absence of an identifiable cause. It may range from a self-limiting condition to a rapidly progressive life-threatening disorder, of which ischaemic stroke is a rare presentation. Such episodes can rarely be the presenting manifestation, and may develop before any other laboratory abnormality or organ involvement. We report a case of HES presented with multiorgan (neurological and renal) involvement, managed successfully with steroids and cytoreductive therapy. High initial absolute eosinophil count can be a clue to the diagnosis and early treatment should be initiated in such patients, to prevent fatal outcomes.

  • haematology (incl blood transfusion)
  • malignant and benign haematology
  • stroke
  • pathology
  • radiology

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  • Contributors All the authors have provided substantial contributions in the clinical management of the case and literature review on the topic in question, have read the final version and approved it, and agree to be accountable for all aspects of the work in copyright. KLB and RB have drafted the manuscript and SKP and KM have revised it critically for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.