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Large pulmonary artery pseudoaneurysm in mucormycosis: successfully managed with surgery and amphotericin
  1. Valliappan Muthu1,
  2. Harkant Singh2,
  3. Ujjwal Gorsi3 and
  4. Ritesh Agarwal1
  1. 1Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  2. 2Cardiovascular and Thoracic Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  3. 3Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr Valliappan Muthu; valliappa{at}

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A 54-year-old woman with poorly controlled diabetes mellitus presented with haemoptysis >400 mL over the last 12 hours. She had been experiencing fever and a productive cough for the past 20 days. She was a non-smoker and had no other illness in the past other than diabetes mellitus. CT of the chest revealed thick-walled cavities in the right upper and middle lobes; a reversed halo sign (RHS) was seen in the right middle lobe (figure 1A). CT pulmonary angiography showed a large pulmonary artery pseudoaneurysm (PAP; 3×2.7×2.5 cm) in the cavity situated in the right lower lobe (figure 1B). Complete blood count revealed haemoglobin of 9 g/dL, the renal and liver functions were normal. Flexible bronchoscopy revealed a clot in the right lower lobe. Sputum and bronchoalveolar lavage fluid did not reveal any organism. She was treated with broad-spectrum antibiotics and liposomal amphotericin B (3 mg/kg) in view of a high likelihood of pulmonary mucormycosis (PM). Right pneumonectomy was performed 5 days after hospitalisation. The postoperative specimen revealed multiple cavities and a large PAP in the right lower lobe. Microscopic examination confirmed the diagnosis of PM (figure 2A,B). The patient was extubated 2 days after surgery and discharged from the hospital after completing 18 days of amphotericin. One-month after the discharge, she was well with no recurrence of fever or haemoptysis and the chest radiograph demonstrated post-pneumonectomy status.

Figure 1

CT showing (A) cavity and reversed halo sign in the right lung and (B) a large pulmonary artery pseudoaneurysm on the right side.

Figure 2

Photomicrographs showing (A) lung cavity with necrotic material (H&E stain,×40) and (B) numerous aseptate thin-walled foldable fungal hyphae in the necrotic cavity (Periodic acid–Schiff (PAS) stain,×400).

PAP is rarely reported in PM and usually has an unfavourable outcome.1–3 In a case series of 32 cases with PM, PAP was observed in one subject.4 The recommended treatment for mucormycosis is liposomal amphotericin B and surgery. While the newer triazoles may have a favourable adverse effect profile, the evidence supporting their use is limited. Transcatheter embolisation has been tried with varying success in few cases of PAP due to mucormycosis.3 5 While there is a role of endovascular treatments in a small arterial aneurysm, they rarely offer a cure in cases of large pseudoaneurysms due to PM.6 The embolisation of PAP can be considered as a bridge for definitive surgery.

Surgery has a definitive role and improves survival in patients with PM. Several patients with PM present with diabetic ketoacidosis, hence timely medical management and stabilisation, followed by surgery within 1–2 weeks of amphotericin therapy is essential. However, large PAP is at risk for rupture and imminent death. In such a scenario, an early surgery (as in our case) may be useful.

Early diagnosis of PM is important since a delay in antifungal is associated with high mortality. A high index of suspicion is required, and timely initiation of antifungal therapy is warranted in the presence of clinicopathologic suspicion of PM. In our index case, a microbiologic or pathologic diagnosis could not be obtained preoperatively, and amphotericin was started based on the imaging finding of RHS in a poorly controlled diabetic.7 8

In conclusion, PAP is a rare complication of PM, and timely amphotericin-B and surgery were lifesaving.

Learning points

  • Large pulmonary artery pseudoaneurysm is an uncommon complication of pulmonary mucormycosis and usually presents as massive haemoptysis.

  • A high index of suspicion is required to diagnose pulmonary mucormycosis.

  • Timely amphotericin B therapy and surgery can be lifesaving.

Ethics statements

Patient consent for publication


Dr Amanjit Bal (Professor, Department of Histopathology) for the histopathology of surgical specimen and providing the photomicrographs of the same.



  • Contributors VM—Conceived the idea, drafted the manuscript and involved in patient management. HS and UG—Involved in patient management, reviewed and approved the manuscript. RA—Involved in patient management, drafted, reviewed and approved the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.