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Convalescent plasma for COVID-19 complicated by ARDS due to TRALI
  1. Kevin Y Wang,
  2. Pratik Shah and
  3. Matthew Pierce
  1. Internal Medicine, Northwell Health, Great Neck, New York, USA
  1. Correspondence to Dr Kevin Y Wang; Kevwangyu{at}


Convalescent plasma, which contains antibodies from recovered individuals, has been used as an effective treatment for infectious diseases in the past and is currently being used as a potential treatment option for COVID-19. Multiple studies have reported this treatment to be safe. We report a case of a patient who developed acute respiratory distress syndrome (ARDS) with features suggestive of transfusion-related acute lung injury after being treated with convalescent plasma for COVID-19. We emphasise the need to be aware of the potential risk of transfusion reactions and disease worsening with convalescent plasma administration and to weigh the risk and benefits of this therapy before administration to patients and propose that further study be done regarding the potential risks of convalescent plasma.

  • haematology (drugs and medicines)
  • immunological products and vaccines
  • haematology (incl blood transfusion)

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  • Contributors KW: provided initial drafting of case report, literature review and refining of case report. PS: provided further literature review and writing of case report. MP: provided guidance as attending and expert, literature review and writing of case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.