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Case report
Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma
  1. Ari D Kappel1,2,
  2. Joshua D Bernstock1,2,
  3. Daniel Francis Ditoro3,4 and
  4. Yi Lu1,2
  1. 1Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA
  2. 2Neurosurgery, Harvard Medical School, Boston, MA, USA
  3. 3Pathology, Brigham and Women's Hospital, Boston, MA, USA
  4. 4Pathology, Harvard Medical School, Boston, MA, USA
  1. Correspondence to Dr Ari D Kappel; akappel{at}bwh.harvard.edu

Abstract

Esthesioneuroblastoma (ENB) is an uncommon sinonasal cancer of the olfactory neuroepithelium that is typically treated with surgical resection followed by radiation therapy. Radiation-induced intracranial osteosarcoma of the skull base is a rare but devastating long-term complication of radiation therapy in this region. Here, we present a case of an 82-year-old patient who developed radiation-induced osteosarcoma of the anterior skull base and paranasal sinuses 10 years after radiation therapy following resection of an ENB. Older patients may be at risk of developing this complication earlier and with a worse prognosis relative to younger patients. Treating physicians/surgeons should be aware of this devastating complication. Patients who are treated with high-dose radiation therapy in this region should be followed for many years.

  • neuroimaging
  • neurooncology
  • radiology
  • ear
  • nose and throat/otolaryngology

https://doi.org/10.1136/bcr-2020-238928

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    Footnotes

    • Contributors All authors (ADK, JDB, DFD and YL) made substantial contributions to the conception and design of the work; the acquisition, analysis or interpretation of data for the work, including drafting the work or revising it critically for important intellectual content and/or final approval of the version to be published.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.