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Lung aspergilloma with pituitary invasive aspergillosis presenting as headache and hyponatraemia
  1. Eunho Choi,
  2. Sun Bean Kim,
  3. Jong Hun Kim and
  4. Young Kyung Yoon
  1. Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
  1. Correspondence to Dr Sun Bean Kim; puppybin{at}


Fungal infections involving the pituitary gland are rare and can be life threatening. A 75-year-old man with hypertension and diabetes mellitus presented with headache and hyponatraemia. Imaging study showed right upper lung mass, and mass resection showed aspergilloma without tissue invasion on histology. The patient developed visual impairment a few weeks later, and MRI of the brain revealed bilateral sphenoid sinusitis and pituitary invasion. The trans-sphenoidal biopsy confirmed invasive Aspergillus infection. His sphenoidal sinuses were endoscopically debrided, and he was treated with oral voriconazole. Pituitary aspergillosis should be considered in the differential diagnosis in patients with lung aspergilloma with headache and sinusitis. Prompt biopsy and antifungal treatment are important due to the high mortality rate of the infection.

  • infectious diseases
  • respiratory medicine
  • otolaryngology / ENT
  • pituitary disorders

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  • Contributors Writing–original draft: EC. Supervision: SBK. Writing–review and editing: SBK, JHK and YKY.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.