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Unforeseen progressive outer retinal necrosis in a child following bone marrow transplant
  1. Anusha Sachan and
  2. Suman Lata
  1. Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, Delhi, India
  1. Correspondence to Dr Suman Lata; suman.dhanda300{at}


A 10-year-old boy underwent stem cell transplant for Hodgkin’s lymphoma and developed vomiting and seizure in the postoperative period. An ophthalmic referral was made from intensive care unit, to rule out papilledema. On examination, there was no papilledema in both eyes, instead there were areas of retinal necrosis with no haemorrhages or vitritis in right eye. Cerebrospinal fluid serology was negative for herpes but MRI showed hyperintensity in temporal lobe. A clinical diagnosis of progressive outer retinal necrosis (PORN) was made and fundus picture was documented with help of a smartphone and 20D lens. High-dose intravenous injection acyclovir was started and PORN lesion improved on treatment.

  • malignant disease and immunosuppression
  • paediatrics (drugs and medicines)
  • paediatric intensive care

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  • Contributors AS and SL had examined the patient and made the diagnosis together. Both of authors had contributed in diagnosing and treating the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.