Article Text

Download PDFPDF
Peritoneal melanosis associated with metastatic melanoma previously treated with targeted and immune checkpoint inhibitor therapy
  1. Kwang Kiat Sim1,
  2. Katie Connell2,
  3. Mayank Bhandari3 and
  4. David Paton2,4
  1. 1Department of General Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  2. 2Anatomical Pathology, Western Diagnostic Pathology, Myaree, Western Australia, Australia
  3. 3Department of General Surgery, Hepatopancreaticobiliary Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  4. 4School of Medicine, Curtin University, Bentley, Western Australia, Australia
  1. Correspondence to Dr Kwang Kiat Sim; kwang.sim{at}health.wa.gov.au

Abstract

Peritoneal melanosis is an uncommon benign condition, the pathophysiology of which is unclear. Macroscopically, it appears as diffuse dark brown or black pigmentation within the peritoneum, mimicking more sinister conditions such as metastatic melanoma. It has been described in a variety of contexts, but only exceedingly rarely in association with metastatic melanoma, with only two previous published case reports. We present a case of peritoneal melanosis associated with metastatic melanoma involving the spleen, previously treated with targeted and immune checkpoint inhibitor therapy. With increasing reports of melanoma regression manifesting as cutaneous tumorous melanosis in patients treated with immune checkpoint inhibitors, we postulate that, similarly, immunotherapy and tumour regression might have a role to play in the pathogenesis of the peritoneal pigmentation in this case.

  • malignant disease and immunosuppression
  • skin cancer
  • general surgery

Statistics from Altmetric.com

Footnotes

  • Contributors Supervised by MB and DP. Patient was under care of MB. Report was written and edited by KKS, DP and MB. Photos prepared by KC.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.