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Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature
  1. Subhash Soni1,
  2. Poonam Elhence2,
  3. Vaibhav Kumar Varshney1 and
  4. Sunita Suman1
  1. 1Department of Surgical Gastroenterology, All India Institute of Medical Sciences Jodphur, Jodhpur, India
  2. 2Department of Pathology, All India Institute of Medical Sciences Jodphur, Jodhpur, India
  1. Correspondence to Dr Subhash Soni; drscsoni{at}


Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

  • gastrointestinal surgery
  • surgical oncology
  • pancreatic cancer
  • chemotherapy
  • pathology

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  • Contributors SS, PE, VKV and SS have made an individual contribution to the writing of the article including planning, conception and design, acquisition of data and interpretation of data, drafting the article. All authors gives final approval of the version published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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