Article Text

Download PDFPDF
Olfactory neurocytoma as a unique cause of chronic SIADH
  1. Mohammad Farwana,
  2. Chrysostomos Tornari,
  3. Ann Sandison and
  4. Pavol Surda
  1. Ear, Nose and Throat / Head and Neck Department, Guy's and St Thomas' Hospitals NHS Trust, London, UK
  1. Correspondence to Dr Mohammad Farwana; farwana94{at}


A 32-year-old man was found to have a nasal mass on DOTATATE positron emission tomography (PET) scan to investigate the cause of his syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient presented 6 years earlier with malignant hypertension followed by a second emergency admission for hyponatraemia. Multiple scans and blood tests over 6 years yielded no cause for his SIADH. Nasendoscopy was unremarkable. A PET scan prompted endoscopic sinus surgery which resulted in the resection of a mass in the anterior hiatus semilunaris. The histological findings were fitting with a diagnosis of a neurocytic-type tumour favouring an olfactory neurocytoma. Following resection, the patient remains well and is cured of his SIADH. An olfactory neurocytoma although rare should be considered as a benign differential for a mass in the nasal space. This case demonstrates how an olfactory neurocytoma can present as a cause of SIADH.

  • ear
  • nose and throat/otolaryngology
  • head and neck cancer
  • endocrine cancer
  • neurooncology
  • adrenal disorders

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors MF, CT and AS conceived the idea of publishing this unique case. Histopathology expertise was provided by PS. The case report was written and submitted by MF.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.