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Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis
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  1. Farida Essajee,
  2. Regan Solomons,
  3. Pierre Goussard and
  4. Ronald Van Toorn
  1. Department of Pediatrics and Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa
  1. Correspondence to Professor Pierre Goussard; pgouss{at}sun.ac.za

Abstract

We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinogen and ferritin levels, consistent with thrombotic complications reported in some adult patients infected with COVID-19. The child also exhibited prolonged viral shedding that suggests severe disease.

  • radiology (diagnostics)
  • infections
  • paediatrics (drugs and medicines)
  • neurology (drugs and medicines)
  • global health

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Footnotes

  • Contributors FE wrote the case presentation and prepared images to be included with the manuscript. RS performed a literature review and wrote the discussion section. RVT assisted with literature review and discussion and also reviewed the paper. PG reviewed the paper and made several modifications to the discussion section.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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