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Case report
Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient
  1. Abuzar Ali Asif1,
  2. Moni Roy1,2 and
  3. Sharjeel Ahmad3
  1. 1Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
  2. 2Department of Internal Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA
  3. 3Department of Internal Medicine, Section of Infectious Diseases, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
  1. Correspondence to Dr Moni Roy; moniroy27{at}


Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma. Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.

  • bone and joint infections
  • drugs: infectious diseases
  • orthopaedics

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  • Contributors AAA, MR and SA created the conception and design of the study. AA wrote in initial manuscript, performed data collection and analysis. MR performed subsequent article revising, data integration and image collection. SA obtained patient consent and performed final manuscript editing. All authors reviewed the final manuscript and approved the final version to be submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.