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Case report
Cornea thinning in two cases of ICE syndrome
  1. Morgan M Harvey1 and
  2. Joseph W Schmitz2
  1. 1Naval Aerospace Medical Institute, Pensacola, Florida, USA
  2. 2Department of Ophthalmology, Naval Medical Center San Diego, San Diego, California, USA
  1. Correspondence to Dr Morgan M Harvey;{at}


We present two patients with a new finding of symmetrical corneal thinning early in the clinical course of iridocorneal endothelial syndrome. Patient 1 was evaluated for uncontrolled angle closure glaucoma of the left eye (OS) status post laser peripheral iridotomy (LPI). After placement of an Ahmed glaucomatous valve and trabeculectomy with mitomycin C were performed, the patient was diagnosed with Chandler syndrome. The patient’s pachymetry at the time of diagnosis revealed stable central corneal thickness (CCT) of 481 µm of the right eye (OD) (baseline 494 µm) and central cornea thinning with CCT of 407 µm OS (baseline 486 µm). Patient 2 was evaluated for ocular hypertension and Chandler syndrome OS was diagnosed. The patient had a good short-term response to LPI and ocular hypotensive medications. This patient was also found to have thinning of his affected cornea with CCT 523 µm OD and 476 µm OS.

  • ophthalmology
  • glaucoma
  • Iris
  • anterior chamber

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  • Contributors MMH wrote the manuscript. JWS managed the patients clinically, acquired the images and revised the manuscript’s contents. Both the authors have approved the final version of the manuscript and agreed to be accountable for the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer The views expressed in this article reflect the results of research conducted by the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government. I am a military service member or federal/contracted employee of the United States government. This work was prepared as part of my official duties. Title 17 USC 105 provides that 'copyright protection under this title is not available for any work of the United States Government.' Title 17 USC 101 defines a US Government work as work prepared by a military service member or employee of the US Government as part of that person's official duties.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.