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Alkalis (most common being lime) are responsible for 60% of the total ocular chemical burns.1 2 Hydroxyl ion released on alkali hydrolysis saponifies the fatty acids in the cell membranes causing cell lysis, facilitating deeper penetration of the alkali. Calcium ion reacts with the tissue, causing fibrosis and calcification.3 Here we report a rare presentation of ocular lime injury. A 5-year-old boy presented to us with the history of lime falling into the left eye, 10 days ago. Immediate management including saline wash and lime particle removal was done at a local hospital and was referred to us for further management. On presentation, visual acuity in the right eye was 20/20 and in the left eye was hand movements at 30 cm (0.005 decimals).4 On slit-lamp examination, the left eye showed 360 degrees patchy limbal blanching with mucous discharge. The cornea was hazy with deep stromal infiltration measuring (3×5) mm in the superior part of the cornea. The anterior chamber could not be visualised due to corneal oedema. Intraocular pressure was digitally normal. The fundal glow was poor and B-scan ultrasonography was normal. It was a severe ocular chemical burn that was graded as Grade IV burn as per Roper-Hall Classification5 and Grade VI as per Dua’s Classification.5 The child did not cooperate for anterior segment optical coherence tomography. Frequent antibiotics, cycloplegics, steroids, prophylactic antiglaucoma drugs, lubricants, sodium citrate and ascorbate were started. Microscope integrated optical coherence tomography (Mi-OCT) guided layer by layer dissection was planned. The intraoperative picture showed 360° limbal ischaemia with associated haemorrhage from friable conjunctiva on the placement of speculum. Mi-OCT showed that infiltrate was in the deep corneal stroma and caused a shadowing effect (figure 1) with intact overlying epithelium. Partial-thickness dissection was started at the edge using a crescent knife. The anterior corneal lamella could be easily dissected off. Repeat Mi-OCT view of the chalky white substance revealed hyper-reflectivity. Status of descemet’s and endothelium could not be assessed. Viscocohesive was injected through the side port and the whitish plaque was cut all-around using Vannas’ scissors and sent for histopathological examination and culture. The defect was closed with an appropriately fashioned corneal patch graft (video 1). A plastic sheet (polythene cover of the intravenous set) was taken to mark the outlines of the defect. The mark was transferred to the donor cornea mounted on an artificial anterior chamber. The donor cornea patch was harvested and sutured to the host bed using 10-0 monofilament nylon. Amniotic membrane graft (AMG) was placed with the epithelial side down and adhered using fibrin glue. AMG was supported at the limbus and lid margin using 8-0 polyglactin suture. Symblepharon ring was placed. Histopathological evaluation of the specimen revealed a dried-up tissue with fibrotic stroma with calcification. The pH of the tissue could not be assessed. Culture did not reveal any growth of a bacterial or fungal organism. Follow-up data could not be acquired as the child was lost to follow-up due to the current pandemic situation.
Sequestered whitish corneal infiltrate is a rare presentation of ocular alkali injury with the differential diagnosis of retained alkali material or tissue reaction to the chemical.
Excisional biopsy is necessary to determine the nature of the sequestration.
The primary intervention is needed to cause adequate healing so that a second stage visual rehabilitative procedure may be undertaken later.
Contributors NS: planning of the treatment. RKB: conducting the procedure, design. DR: acquisition of data. RS: interpretation and analysis of results.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Parental/guardian consent obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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