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Case report
Microsatellite instability driven metastatic parathyroid carcinoma managed with the anti-PD1 immunotherapy, pembrolizumab
  1. Daniel Park1,
  2. Rany Airi1 and
  3. Michael Sherman2
  1. 1Internal Medicine, Touro University California, Vallejo, California, USA
  2. 2Hematolgy & Oncology, Contra Costa Oncology, Walnut Creek, California, USA
  1. Correspondence to Daniel Park; Daniel.park2{at}


The present case report describes a 65-year-old man with Lynch syndrome and hypercalcaemia associated with hyperparathyroidism. Parathyroid surgery confirmed the diagnosis of parathyroid carcinoma. Serum calcium and parathyroid hormone (PTH) concentrations serially increased after initial surgery. Imaging study and subsequent biopsy confirmed lung metastases with mismatch repair deficiency. Pembrolizumab was initiated achieving 60% reduction in tumour burden.

  • oncology
  • cancer intervention

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  • Contributors DP: medical student, drafted the case report; RA: medical student, assisted with literature review and revisions; MS: attending physician who determined treatment plan and management.

  • Funding This study was funded Touro University California (grant number: 652158).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.