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Case report
Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium
  1. Liesel Elisabeth Hardy1,2,
  2. Zia Chaudry2,3,
  3. King Wan1 and
  4. Chloe Ayres1
  1. 1Gynaecology Oncology, King Edward Memorial Hospital for Women Perth, Subiaco, Western Australia, Australia
  2. 2Anatomical Pathology, PathWest Laboratory Medical WA, Nedlands, Western Australia, Australia
  3. 3Anatomical Pathology, King Edward Memorial Hospital for Women Perth, Subiaco, Western Australia, Australia
  1. Correspondence to Dr Liesel Elisabeth Hardy; lieselhardy{at}


Endometrial large-cell neuroendocrine carcinoma admixed with a high-grade serous (HGS) adenocarcinoma is extremely rare with only one reported case in the literature. We present the second reported case in a 47-year-old woman who presented with abdominal pain, distension and loss of weight. On examination she had a fixed pelvic mass and vascular left vaginal mass. Imaging confirmed a 13 cm solid cystic rectouterine pelvic mass, omental disease and retroperitoneal lymphadenopathy. She underwent a modified posterior exenteration, partial posterior vaginectomy, omentectomy and Hartmanns procedure with suboptimal debulking. Histopathology revealed a stage 4B mixed carcinoma with large cell neuroendocrine (70%) and HGS carcinoma (30%). Eight cycles of adjuvant cisplatin and paclitaxel were given with a complete radiological and biochemical response after 7 months. Unfortunately, she developed widespread recurrence at 9 month and was offered second line chemotherapy.

  • obstetrics and gynaecology
  • gynecological cancer
  • chemotherapy
  • radiotherapy

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  • Contributors LEH drafted the manuscript. ZC provided the histopathology images and revised the manuscript. KW revised the manuscript. CA revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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