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Case report
Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options
  1. Ahmed Ghoneima1,2,
  2. Joanna Cooke3,
  3. Emily Shaw4 and
  4. Avi Agrawal5
  1. 1Edinburgh Surgical Sciences Qualification, The University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, UK
  2. 2Department of General Surgery, Portsmouth Hospitals National Health Service Trust, Portsmouth, UK
  3. 3Department of Pathology, Portsmouth Hospitals National Health Service Trust, Portsmouth, UK
  4. 4Department of Pathology, Southampton University Hospitals National Health Service Trust, Southampton, UK
  5. 5Department of Breast and Endocrine Surgery, Portsmouth Hospitals NHS Trust, Portsmouth, UK
  1. Correspondence to Ahmed Ghoneima; ahmed.seif.ghoneima{at}


We present this case of human herpes virus 8-positive germinotropic lymphoproliferative disorder in a 20-year-old woman seen in the surgical oncology clinic for localised lymphadenopathy. This is the first case to be reported in the UK, and we discuss it along with a literature review including investigations and treatment options. This will demonstrate the importance of preoperative workup and multidisciplinary teamwork in deciding management plans and serve as a guide for future encounters of this rare condition in clinical practice.

  • surgical oncology
  • pathology

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  • Contributors AG the main and corresponding author of this case report including the literature search and discussion. JC provided the histopathology reports, images and contributed to the editing of the manuscript. ES made the diagnosis and provided support from a pathology perspective and AA was the operating surgeon and contributed to the editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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