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Case report
Acquired haemophilia a secondary to multiple myeloma: management of a patient with a mechanical mitral valve
  1. Lisa B Pinchover1,
  2. Rami Alsharif2 and
  3. Talia Bernal3
  1. 1Anesthesiology, NewYork-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, USA
  2. 2Hematology/Oncology, George Washington University Medical Faculty Associates, Washington, DC, USA
  3. 3Department of Medicine, Duke University Health System, Durham, NC, USA
  1. Correspondence to Dr Lisa B Pinchover; lbp9003{at}


A 77-year-old man with a mechanical mitral valve on warfarin presented with an acute drop in haemoglobin and large spontaneous haematoma. He was found to have a new coagulopathy with initial labs notable for a prolonged activated partial thromboplastin time (APTT). Further workup revealed factor VIII levels less than 1%, abnormal mixing studies and elevated Bethesda titres, which was consistent with an acquired factor VIII inhibitor. Given his bone marrow biopsy result, which was positive for plasma cell myeloma, this coagulopathy was thought to be an acquired haemophilia A secondary to multiple myeloma. Anticoagulation was a challenge in this patient given his mechanical mitral valve and acquired haemophilia A. Although the patient was at risk of thrombosis due to a mechanical mitral valve, he had a bleeding diathesis and anaemia not responsive to transfusion. The decision was made to hold anticoagulation and the patient was started on myeloma treatment which included CyBorD, rituximab and daratumumab. After initiation of treatment APTT and factor VIII normalised. He eventually restarted anticoagulation under direction of his primary care doctor.

  • haematology (drugs and medicines)
  • medical management
  • haematology (incl blood transfusion)
  • valvar diseases

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  • Contributors LBP: Resident who admitted and took care of the patient throughout admission. Completed the write up, literature search and is the corresponding author. RA: Hematology fellow who was consulted while the patient was admitted. Assisted with literature search and editing of case report. TB: Attending on service during the patients admission. Assisted with writing and editing case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.