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Case report
COVID-19-associated brief psychotic disorder
  1. Colin M Smith1,2,
  2. Jonathan R Komisar1,2,
  3. Ahmad Mourad2 and
  4. Brian R Kincaid1,2
  1. 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
  2. 2Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
  1. Correspondence to Dr Colin M Smith; colin.smith{at}


A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

  • psychotic disorders (incl schizophrenia)
  • infectious diseases
  • psychiatry

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  • Contributors CMS wrote the draft of the introduction and discussion of the manuscript, while JRK and AM wrote the draft of the case presentation, while participating in clinical care and clinical data extraction for the case. CMS, JRK, AM and BRK reviewed the literature and participated in data interpretation. BRK oversaw the clinical care of the patient. All authors contributed to the final writing, analysis and revising of the article, gave approval for the final version to be published and agree to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer The views expressed in the article are solely the opinions of the authors and do not necessarily reflect the official policies of the U.S. Department of Health and Human Services or the Indian Health Service.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.