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Case report
Parvovirus B19 infection masquerading as relapsed acute lymphoblastic leukaemia following haematopoietic stem cell transplantation
  1. Trisha Larkin1,
  2. Peng Li2 and
  3. Biljana Horn3
  1. 1Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA
  2. 2Department of Pathology, ARUP Laboratories, Salt Lake City, Utah, USA
  3. 3Department of Pediatrics, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Trisha Larkin; trisha.larkin{at}stjude.org

Abstract

A 7-year-old boy presented with a constellation of bone pain, a skeletal lesion, and pancytopenia after undergoing allogeneic haematopoietic stem cell transplantation for recurrent acute B-cell lymphoblastic leukaemia. Investigations to rule out leukaemia recurrence were unremarkable. Due to presence of maturation arrest in erythropoiesis with giant pronormoblasts and aberrant intranuclear inclusions on a bone marrow aspirate, parvovirus B19 (PVB-19) staining was completed and confirmed the diagnosis of disseminated PVB-19. Though PVB-19 infection after solid organ transplantation was reported in the literature as early as 1986, acquired PVB-19 viremia presenting with a solitary bone lesion is a novel presentation in paediatrics.

  • paediatrics
  • cancer intervention
  • pathology

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Footnotes

  • Twitter @dr_trishak

  • Contributors TL, MD, MBA was primary author of the manuscript and responsible for revising it critically for important intellectual content. She participated in analysis and interpretation of data for the work. PL, MD, PhD participated in analysis and interpretation of the data for the work and in revising the manuscript for important intellectual content. BH, MD participated in analysis and interpretation of the data for the work and in revising the manuscript for important intellectual content. She also lead efforts for patient management.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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