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Case report
Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmic
  1. Layan El-khatib,
  2. Hussayn Alrayes,
  3. Omar Sallam and
  4. Ahmed Elbanna
  1. Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
  1. Correspondence to Dr Layan El-khatib; lelkha1{at}


Quinidine is one of the oldest antiarrhythmics known. Over the years, its use has decreased along with its side effects. Our case describes a 69-year-old woman with recurrent resistant ventricular tachycardia on Quinidine and Amiodarone who presented with acute liver toxicity. Drug-induced liver toxicity was at the top of our differential diagnosis list. Taking multiple factors into consideration, a decision was made to discontinue Quinidine, the patient’s symptoms and lab abnormalities resolved within 1 week, yielding the diagnosis of Quinidine hypersensitivity.

  • arrhythmias
  • pacing and electrophysiology
  • cardiovascular system
  • liver disease
  • unwanted effects/adverse reactions

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  • Contributors LEK helped in data collection and writing of the case report. HA, OS and AE performed case revision and editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.