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Case report
Unusual behaviour of an unusual tumour: calcitriol-induced hypercalcaemia in metastatic oesophageal neuroendocrine carcinoma
  1. Filip Ionescu1,
  2. Ioana Petrescu1 and
  3. Maria Marin2
  1. 1Department of Internal Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA
  2. 2Department of Nephrology, William Beaumont Hospital, Royal Oak, Michigan, USA
  1. Correspondence to Dr Filip Ionescu; filip.ionescu{at}


Hypercalcaemia in malignancy is most commonly caused by paraneoplastic secretion of parathyroid hormone-related protein or osteolytic metastases. Very rarely (<1% of cases), the mechanism behind increased serum calcium is increased production of calcitriol (1,25-dihydroxyvitamin D) and even rarer is the occurrence of this phenomenon in solid malignancies, with few such instances reported in the literature. We present a case of a neuroendocrine malignancy originating in the oesophagus associated with calcitriol-induced hypercalcaemia, a phenomenon that has not been previously described. We review the pathophysiology of calcitriol-induced hypercalcaemia and previously reported cases of solid tumours with this presentation.

  • calcium and bone
  • oesophageal cancer

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  • Contributors FI: drafting and editing of the manuscript and review of literature. IP and MM: drafting and editing of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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