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Case report
Chemoradiation therapy for oesophageal cancer with airway stenosis under mechanical ventilation with light sedation using dexmedetomidine alone
  1. Takashi Gondo,
  2. Tomohiro Sonoo,
  3. Hideki Hashimoto and
  4. Kensuke Nakamura
  1. Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan
  1. Correspondence to Dr Takashi Gondo; t.gondo.0222{at}


For malignant tumours, treatment is rarely indicated in cases requiring mechanical ventilation management because such intensive care would engender a decrease in performance status. However, light sedation using dexmedetomidine might enable chemoradiation while accommodating activities of daily living. We experienced two cases of fatal tracheal invasion and airway stenosis of stage Ⅳ oesophageal cancer that were treated with chemoradiation or radiation under mechanical ventilation (one case was differential lung ventilation.) with dexmedetomidine alone and rehabilitation was performed under a ventilator. Early mobilisation by light sedation with dexmedetomidine can inhibit performance status decline attributable to mechanical ventilation. Bridging tracheal intubation with light sedation by dexmedetomidine for temporary chemoradiation therapy to reduce tumour volume might present a good alternative for patients with malignant tumour.

  • cancer intervention
  • mechanical ventilation
  • oesophageal cancer

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  • Contributors KN planned and TG wrote this article. TS and HH and KN revised.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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