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Case report
Diagnosis of Kikuchi-Fujimoto disease in an 11-year-old girl with fever and sickle cell disease
  1. Laura Cannon1,
  2. Endi Wang2 and
  3. Mara Becker1
  1. 1Division of Pediatric Rheumatology, Department of Pediatrics, Duke Children's Hospital and Health Center, Durham, North Carolina, USA
  2. 2Department of Pathology, Duke University Hospital, Durham, North Carolina, USA
  1. Correspondence to Dr Laura Cannon; LauraACannon86{at}


Kikuchi-Fujimoto disease (KFD) is a rare lymphohistiocytic disorder which can cause prolonged fever and other systemic B symptoms including diffuse lymphadenopathy. Given its clinical presentation, there is often initial concern for lymphoma and diagnosis requires lymph node biopsy. It most frequently affects young women of Asian descent; it is less commonly encountered in paediatric patients. KFD is typically a benign, self-limited process, however, there is an association with development of systemic lupus erythematosus. Given its rarity, it remains unclear if KFD is associated with other chronic conditions. Here we present the third case of KFD occurring in a paediatric patient with sickle cell disease.

  • paediatrics
  • rheumatology
  • systemic lupus erythematosus
  • sickle cell disease

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  • Contributors LC drafted the initial manuscript and revised the manuscript. EW and MB critically reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agreed to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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