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Case report
Pancytopenia and TTP-like picture secondary to pernicious anaemia
  1. Peiting Chen,
  2. Preethi Ramachandran,
  3. Karan Josan and
  4. Jen Chin Wang
  1. Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, New York, USA
  1. Correspondence to Dr Preethi Ramachandran; drpreethiram{at}


A 21-year-old man presented to the emergency department with generalised weakness, weight loss and decreased appetite for few weeks. He had evidence of severe pancytopenia and haemolysis. His peripheral smear with many schistocytes was suspicious for thrombotic thrombocytopenic purpura (TTP). He was supported with blood transfusions and daily plasmapheresis. His platelet counts worsened despite 4 days of therapy. Bone marrow biopsy was significant for hypercellular bone marrow with megaloblastic changes. Further workup revealed normal ADAMTS13 level, low vitamin B12, positive intrinsic factor antibodies and high methylmalonic acid. Diagnosis of pernicious anaemia was established and he was started on daily treatment with intramuscular vitamin B12 which subsequently improved his symptoms and haematological parameters. This report highlights the importance of checking vitamin B12 level in patients presenting with pancytopenia and TTP-like picture before making a diagnosis of TTP.

  • nutrition
  • haematology (incl blood transfusion)
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  • Contributors PC wrote the manuscript, PR and KJ did the literature review and JCW supervised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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