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Case report
Tissue glue: a potential role in the management of intraoperative oesophageal perforation
  1. Sushil Rodrigues Ranjan1,
  2. Samit Majumdar2,
  3. Jaiganesh Manickavasagam3,4 and
  4. Susanne Flach5
  1. 1School of Medicine, University of Dundee, Dundee, UK
  2. 2ENT Department, Ninewells Hospital, Dundee, UK
  3. 3Department of Otorhinolaryngology, Ninewells Hospital, Dundee, UK
  4. 4Tayside Academic Science Centre, University of Dundee, Dundee, UK
  5. 5Otorhinolaryngology and Head & Neck Surgery, Hospital of the Ludwig‐Maximilians‐University, Munich, Germany
  1. Correspondence to Jaiganesh Manickavasagam; jaiganesh.manickavasagam{at}


An 85-year-old man suffering from oropharyngeal dysphagia due to a pharyngeal pouch and cricopharyngeal spasm underwent endoscopic stapling of the pouch under general anaesthesia. During the procedure, an iatrogenic perforation of the oesophagus was noticed. After considering several options, 5 mL of Tisseel tissue glue was used to seal the perforation intraoperatively. The patient was started on intravenous co-amoxiclav, kept nil by mouth and fed via a nasogastric tube. After 4 days of observation mediastinal collection and any leakage was ruled out with a gastrografin contrast swallow procedure. At this point he was considered safe for oral intake.

  • cancer intervention
  • ear, nose and throat/otolaryngology
  • gastroenterology
  • oesophagus

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  • Contributors SRR contributed to the write-up of the case report. JM and SM aided with the acquisition and interpretation of the patient case details and subsequently helped with their proof-reading skills and approval of the case report’s final version. SF contributed with her proof-reading skills and approval of the case report’s final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.