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Case report
Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice


A case of a 59-year-old man with resistant hypertension, despite 8 months of non-pharmacological and pharmacological management up to maximal doses of triple antihypertensive therapy. Review of the literature found a study that reported improved blood pressure control with bedtime dosing of antihypertensive treatment. Changing to bedtime dosage of antihypertensives resulted in significant improvement in blood pressure control to below target levels. This highlights the importance of the clinicians’ awareness and implementation of research findings and hence delivery of best evidence-based care.

  • hypertension
  • cardiovascular medicine
  • general practice / family medicine

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