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Case report
Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice
  1. Timothy Yap1,
  2. Jacquita S Affandi2,
  3. Christopher M Reid2 and
  4. Dan Xu3,4
  1. 1Curtin Medical School, Curtin University, Perth, Western Australia, Australia
  2. 2School of Public Health, Curtin University, Perth, Western Australia, Australia
  3. 3Department of General Practice, Curtin University Bentley Campus, Perth, Western Australia, Australia
  4. 4Department of Medical Education, Sun Yan-sen University of Medical Sciences, Guangzhou, China
  1. Correspondence to Professor Dan Xu; daniel.xu{at}


A case of a 59-year-old man with resistant hypertension, despite 8 months of non-pharmacological and pharmacological management up to maximal doses of triple antihypertensive therapy. Review of the literature found a study that reported improved blood pressure control with bedtime dosing of antihypertensive treatment. Changing to bedtime dosage of antihypertensives resulted in significant improvement in blood pressure control to below target levels. This highlights the importance of the clinicians’ awareness and implementation of research findings and hence delivery of best evidence-based care.

  • hypertension
  • cardiovascular medicine
  • general practice / family medicine

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  • Contributors TY designed a part of the initial draft and edited and reviewed the final manuscript. JA and CR reviewed and edited the initial and final manuscript. DX designed the initial draft and reviewed and edited the initial and final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.