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Case report
Primary Sjogren’s syndrome manifesting with distal renal tubular acidosis and severe metabolic bone disease
  1. Gitanjali Jain1,
  2. Suprita Kalra1,
  3. Gautam Vasnik2 and
  4. Sumit Bhandari3
  1. 1Department of Pediatrics, Army Hospital Research and Referral, New Delhi, Delhi, India
  2. 2Department of Pathology, Army Hospital Research and Referral, New Delhi, Delhi, India
  3. 3Department of Orthopaedics, Army Hospital Research and Referral, New Delhi, Delhi, India
  1. Correspondence to Dr Suprita Kalra; kalrasuprita{at}gmail.com

Abstract

Sjogren’s syndrome (SS) is a chronic, autoimmune, inflammatory disorder affecting primarily the salivary and lacrimal glands with potential for systemic involvement. The disease predominantly occurs in women in the age group of 35–45 years and is relatively rare in children. It mainly affects salivary and lacrimal glands with potential for systemic involvement. Children presenting with the severe metabolic bone disease at the very outset has not been reported in the paediatric literature. We report a 13-year-old girl who presented with pain in multiple large joints with predominant involvement of hip joints leading to difficulty in walking for the past 6 months and unintentional weight loss of the same duration. Investigations revealed distal renal tubular acidosis with severe metabolic bone disease as an extra-glandular manifestation of primary SS.

  • musculoskeletal and joint disorders
  • paediatrics (drugs and medicines)
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Footnotes

  • Contributors GJ conceived the study, wrote the manuscript and was in charge of overall direction and planning. GV and SB helped with laboratory investigations of the patient and contributed to the manuscript. SK managed the case, supervised the findings of this work and directed the author and co-authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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