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Case report
Pituitary metastasis of prostate cancer presenting as a unilateral third nerve palsy
  1. Sajjad Ahmad1,
  2. Fiona Smeeton2,
  3. Caroline Hayhurst3 and
  4. Andrew Lansdown1
  1. 1Diabetes and Endocrinology, University Hospital of Wales, Cardiff, Wales, UK
  2. 2Department of Diabetes and Endocrinology, Nevill Hall Hospital, Abergavenny, Monmouthshire, UK
  3. 3Division of Neurosurgery, University Hospital of Wales, Cardiff, UK
  1. Correspondence to Dr Sajjad Ahmad; drsajjad618{at}yahoo.com

Abstract

A 60-year-old man presented with right third nerve palsy and headaches. Neuroimaging showed a pituitary lesion. There was evidence of rapid enlargement on interval scans, invasion of the cavernous sinus and displacement of the pituitary stalk. He subsequently developed anterior hypopituitarism. CT thorax, abdomen and pelvis did not show any evidence of malignancy. This was thought to be an aggressive pituitary macroadenoma but histology post-trans-sphenoidal surgery surprisingly showed metastasis from an undiagnosed prostate primary. His prostate specific antigen was raised and MRI pelvis confirmed locally advanced prostate cancer.

  • pituitary disorders
  • prostate cancer
  • radiotherapy
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Footnotes

  • Contributors SA, consultant physician/Endocrinologist, wrote case report and discussion with literature search and references. Obtained informed consent from patient. FS, consultant physician/ Endocrinologist, reviewed and authorised the final version of the abstract. CH, consultant Neurosurgeon, reviewed and authorised the final version of the abstract. AL, consultant physician/ Endocrinologist, reviewed and authorised the final version of the abstract.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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