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Case report
CMV coinfection in treatment refractory immune checkpoint inhibitor colitis
  1. Kevin B Harris1,
  2. Pauline Funchain2 and
  3. Brian B Baggott3
  1. 1Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  2. 2Department of Hematology and Oncology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  3. 3Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  1. Correspondence to Dr Kevin B Harris; harrisk5{at}


As immune checkpoint inhibitors (ICIs) are increasingly used, clinicians are more frequently encountering the side effects of these therapies. ICIs have been implicated in numerous adverse effects against healthy tissues. We present a case of a patient who developed treatment refractory checkpoint inhibitor colitis. Following colonoscopy, it was discovered that this patient had cytomegalovirus (CMV) coinfection. This case report highlights the importance of undertaking an appropriate assessment, including endoscopic and histologic investigation, of patients with presumed ICI colitis. Accurately diagnosing a superimposed CMV colitis changes clinical management and can improve patient outcomes.

  • gastroenterology
  • oncology
  • hepatitis and other GI infections
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  • Contributors KBH: primary author of the manuscript. PF: edited the manuscript. BBB: edited the manuscript and is the article guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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