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Case report
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of pancreas: a rare entity—worth to note
  1. Bharti Varshney1,
  2. Jyotsna Naresh Bharti1,
  3. Vaibhav Kumar Varshney2 and
  4. Taruna Yadav3
  1. 1Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
  2. 2Surgical Gastroenterology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
  3. 3Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
  1. Correspondence to Dr Vaibhav Kumar Varshney; drvarshney09{at}


Mixed adenocarcinoma with neuroendocrine tumour of pancreas has been reported infrequently and consists of both epithelial and neuroendocrine component. We encountered an 81-year-old male patient who presented with clinical features of painful progressive jaundice for 1 month. Contrast-enhanced CT abdomen reported a mass in the pancreatic head with dilated common bile duct and pancreatic duct. He underwent pancreatoduodenectomy and histopathological examination revealed two different tumours: ductal adenocarcinoma admixed with neuroendocrine tumour of pancreas. He received adjuvant chemotherapy, and at the end of 1-year follow-up, he has no recurrence. Here, we reported this rare malignancy of pancreas for which pancreatoduodenectomy was done and diagnosed on histopathology with immunohistochemistry.

  • adenocarcinoma
  • neuroendocrine
  • mixed
  • pancreas
  • pancreatoduodenectomy

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  • Contributors VKV was involved as the treating surgeon and in patient management. BV, JNB and TY were involved in the diagnosis of disease. BV, JNB and VKV were involved in writing the initial draft of the manuscript. All authors contributed to refining the study and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.