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Rare disease
Case report
Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma
  1. Moyosore D Awobajo1,
  2. Ara A Vaporciyan2,
  3. Charles Lu3 and
  4. Saumil J Gandhi1
  1. 1Thoracic Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  2. 2Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  3. 3Thoracic Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  1. Correspondence to Dr Moyosore D Awobajo; mdawobajo{at}mdanderson.org

Abstract

A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour, curative radiation with stereotactic body radiation therapy (SBRT) to the right upper lobe primary tumour was planned as patient was deemed not to be a surgical candidate. Repeat imaging with a CT chest 2 months after SBRT demonstrated good local control of the primary disease in the right upper lobe despite rapidly advancing distant metastasis. The patient continues systemic therapy with pembrolizumab, to which she has shown good response.

  • lung cancer (oncology)
  • radiotherapy
  • pathology

http://dx.doi.org/10.1136/bcr-2020-234779

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    Footnotes

    • Contributors Supervised by SJG. Patient was under the care of SJG, AAV and CL. Report was written by MDA and edited by SJG, AAV and CL.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.