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Case report
Dramatic recovery of vision in patient with acute central retinal artery occlusion treated with local intra-arterial tissue plasminogen activator
  1. Edward A Margolin1,
  2. Amrit Rai1,
  3. Jeremy Goldfarb1,
  4. Kirill Zaslavsky1,
  5. Radha Kohly1 and
  6. Patrick Nicholson2
  1. 1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Medical Imaging, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to Dr Edward A Margolin; edmargolin{at}


Central retinal artery occlusion (CRAO) is a devastating disease resulting in severe visual loss in most cases. It has no proven treatment, and a variety of management options used clinically all have dismal rate of success. We report outcome of treatment with local intra-arterial thrombolysis administered 2.75 hours after devastating visual loss from incomplete CRAO.

  • retina
  • eye

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  • Contributors All authors contributed equally to data acquisition and manuscript write up and critical appraisal. EAM: data acquisition, concept, writing up of the first draft and literature review. AR: review of the literature, acquisition of figures and critical review of manuscript. JG: acquisition and preparation of figures, review of the draft and literature review. KZ: preparation of figures, review of the manuscript and literature review. RK: writing of the manuscript and revision. PN: aquisition of figures and critial review of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.